Opinion on genotoxicity testing strategies
The Scientific Committee reviewed the current state-of-the-science on genotoxicity testing and provided a commentary and recommendations on genotoxicity testing strategies. A step-wise approach is recommended for the generation and evaluation of data on genotoxic potential, beginning with a basic battery of in vitro tests, comprising a bacterial reverse mutation assay and an in vitro micronucleus
2010-08-02
2010-08-02 ヘルスカナダはナトリウム削減報告書を歓迎 ヘルスカナダ Government of Canada Welcomes Sodium Reduction Report July 29, 2010 http://www.hc-sc.gc.ca/ahc-asc/media/nr-cp/_2010/2010_131-eng.php Leona Aglukkaq保健大臣はナトリウム削減関係者ワーキンググループによる「カナダの減塩戦略」の発表を歓迎する… 2010-08-02 モントリオール市場で偽バイアグラが見つかった ヘルスカナダ Counterfeit Viagra Found on the Montréal Market July 29, 2010 http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/_2010/2010
2009-12-24
2009-12-24 報告書各種 RIVM ほとんどオランダ語 遺伝毒性発がん性物質の基準設定。ヒト毒性学的リスク限度とMPC Standard setting for genotoxic carcinogens. Human-toxicological risk limits and MPC 2009-12-17 http://www.rivm.nl/bibliotheek/rapporten/601782027.html 遺伝毒性… 2009-12-24 お祝いの食べ残しを埋め立て地に捨てるのはやめよう DEFRA Benn: let’s stop feeding our festive leftovers to landfill 23 December 2009 http://www.defra.gov.uk/news/2009/091223c.htm Defraの新しい調査の結果か
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http://www.gta-us.org/2008Presentations/Kenyon.pdf
Prediction of rodent carcinogenic potential of naturally occurring chemicals in the human diet using high-throughput QSAR predictive modeling - PubMed
Genetic toxicity assessment: employing the best science for human safety evaluation part VI: when salt and sugar and vegetables are positive, how can genotoxicity data serve to inform risk assessment? - PubMed
Quantitative assessment of cumulative carcinogenic risk for multiple genotoxic impurities in a new drug substance - PubMed
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens II. Further analysis of mammalian cell results, relative predictivity and tumour profiles - PubMed
In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results